{"id":537,"date":"2024-06-05T16:53:06","date_gmt":"2024-06-05T14:53:06","guid":{"rendered":"https:\/\/francescodellavalle.foundation\/neuroinflammation\/"},"modified":"2024-07-11T11:52:27","modified_gmt":"2024-07-11T09:52:27","slug":"neuroinflammation","status":"publish","type":"page","link":"https:\/\/francescodellavalle.foundation\/en\/neuroinflammation\/","title":{"rendered":"Neuroinflammation"},"content":{"rendered":"\n
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Neuroinflammation is a defence mechanism that brings into play our body\u2019s crucial nervous and immune systems.It is activated in response to infection and other aggressive factors, making it a key mechanism underlying different physiological and pathological conditions. When neuroinflammation gets out of control, it no longer performs a protective function but becomes an effector of damageLearning to modulate it provides a new way of protecting and restoring human (and also animal) health.<\/p>\n<\/div>\n<\/div>\n\n\n\n

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Nerve sprouting mediated by the Nerve Growth Factor<\/em>Original drawing by Rita Levi Montalcini,<\/em>Rio de Janeiro, 20 December 1952<\/em>Dedicated to Francesco della Valle, 22 July 1991<\/em>Private collection Francesco della Valle Foundation<\/em>Reproduction prohibited<\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n

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From neurodegeneration to neuroinflammation: the evolution of neuroscience<\/h2>\n\n\n\n
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The \u201cneuronocentric\u201d outlook, focusing exclusively on the neuron and the degenerative processes that can affect it, has gradually evolved in recent years. Glial cells, once thought of as merely a supporting glue between neurons, are now recognised as central participants in brain function with functional roles that go well beyond structural purposes and that are absolutely crucial both for maintaining central nervous system homeostasis and the pathogenesis of dysfunctional processes.<\/p>\n\n\n\n

As a result, neurodegeneration<\/strong>is increasingly considered in terms of neuroinflammation.<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

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\"Oligodendrocytes\"<\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n
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Pain in the third millennium: more than just neurons<\/h2>\n\n\n\n

According to the definition adopted by the IASP (International Association for the Study of Pain – 2020) and the World Health Organization, pain is \u201can unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage\u201d.<\/p>\n\n\n\n

Although, on the one hand, neurons are the undisputed protagonists of such an unpleasant experience, on the other it is increasingly obvious that their sensitivity is influenced by other \u201cnon-neuronal\u201d cells, first and foremost the microglia.<\/p>\n\n\n\n

Modulating these interactions therefore opens new scenarios for intervening effectively on pain, particularly pain of a chronic nature (for instance that associated with osteoarthritis), but also visceral pain caused by cystitis or endometriosis, the purely neuropathic pain typical of diabetic neuropathy, as well as the widespread pain that characterises algo-dysfunctional syndromes, such as fibromyalgia.<\/p>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Neuroinflammation is a defence mechanism that brings into play our body\u2019s crucial nervous and immune systems. It is activated in response to infection and other aggressive factors, making it a key mechanism underlying different physiological and pathological conditions. When neuroinflammation gets out of control, it no longer performs a protective function but becomes an effector […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-537","page","type-page","status-publish","hentry"],"yoast_head":"\nNeuroinflammation - Fondazione Francesco della Valle ETS<\/title>\n<meta name=\"description\" content=\"Learning to modulate neuroinflammation represents a new way to protect and restore human and animal health.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/francescodellavalle.foundation\/en\/neuroinflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuroinflammation - Fondazione Francesco della Valle ETS\" \/>\n<meta property=\"og:description\" content=\"Learning to modulate neuroinflammation represents a new way to protect and restore human and animal health.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/francescodellavalle.foundation\/en\/neuroinflammation\/\" \/>\n<meta property=\"og:site_name\" content=\"Fondazione Francesco della Valle ETS\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-11T09:52:27+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/francescodellavalle.foundation\/wp-content\/uploads\/2024\/06\/IMG_4937-1024x800.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/francescodellavalle.foundation\/en\/neuroinflammation\/\",\"url\":\"https:\/\/francescodellavalle.foundation\/en\/neuroinflammation\/\",\"name\":\"Neuroinflammation - 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